Objectives: This study was designed to test the hypothesis that osteopontin (OPN) and some proteins previously correlated with OPN, low-density lipoprotein receptor (LDLR), dynamin 2 (DNM2), fibronectin-1 (FN1), and 2-oxoglutarate dehydrogenase-like (OGDHL), are potential risk markers for SCD, and may reflect modifiable molecular pathways in patients with DM and HFpEF. However, there are no known biomarkers in the population with DM and HFpEF to predict SCD risk. Miller School of Medicine, Miami, FL, United Statesīackground: Diabetes mellitus (DM) is associated with increased risk of sudden cardiac death (SCD), particularly in patients with heart failure with preserved ejection fraction (HFpEF). 9Peggy and Harold Katz Family Drug Discovery Center, University of Miami Leonard M.8Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland.7American Heart Association, Dallas, TX, United States.Miller School of Medicine, Miami, FL, United States 6Miami VA Healthcare System, University of Miami Leonard M.5Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL, United States.
2Interdisciplinary Stem Cell Institute, University of Miami Leonard M.1Division of Cardiology, Department of Medicine, University of Miami Leonard M.Myerburg 1,7, Juhani Junttila 8*‡ and Lina A. Goldberg 4, Anastasios Lymperopoulos 5, Leonardo J. Mausam Patel 1 †, Daniela Rodriguez 2 †, Keyvan Yousefi 1,2,3 †, Krista John-Williams 1, Armando J.
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